Description

Trifluoroacetic Acid Benzyl Ester is a versatile fluorinated organic compound, also known as Benzyl Trifluoroacetate. This specialty chemical is valued for its role as a protecting group reagent and a key building block in complex organic syntheses, particularly in the pharmaceutical and agrochemical sectors. Its primary utility lies in introducing the trifluoroacetyl moiety, which can impart desirable metabolic stability and lipophilicity to target molecules. Industries requiring advanced fine chemical intermediates, such as pharmaceutical R&D, agrochemical production, and material science, are the primary users of this high-purity reagent.

Application

• Pharmaceutical Intermediate: A crucial reagent in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring trifluoroacetyl protection of amines or alcohols.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the trifluoromethyl group enhances biological activity.
• Peptide Chemistry: Serves as a protecting group agent for amino acids during solid-phase peptide synthesis (SPPS).
• Organic Synthesis Building Block: Employed in various reactions, including esterifications and acylations, to construct complex molecular architectures in R&D laboratories.
• Material Science Precursor: Acts as a monomer or modifying agent in the development of specialty polymers and coatings with unique surface properties.
• Liquid Crystal & OLED Material Research: Utilized in the synthesis of fluorinated organic compounds for electronic and display applications.

Basic Information

Product Name	Trifluoroacetic Acid Benzyl Ester
CAS No.	351-70-2
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	Benzyl Trifluoroacetate; Trifluoroacetic Acid Benzyl Ester; α,α,α-Trifluoroacetic Acid Phenylmethyl Ester; Benzyl α,α,α-Trifluoroacetate; Phenylmethyl Trifluoroacetate; BnTFA; TFA-Benzyl Ester; Benzyl Ester of Trifluoroacetic Acid
EINECS	206-517-8

Quality Control

Our Trifluoroacetic Acid Benzyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container must be kept tightly sealed due to the compound's sensitivity to moisture and potential volatility.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.410 - 1.415
Density (g/mL at 20°C)	1.23 - 1.25

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.