Description

Ethyl 2-Methyl-4,4,4-Trifluoroacetoacetate is a versatile fluorinated β-ketoester building block, prized for its ability to introduce the trifluoromethyl group into complex molecular architectures. This compound is essential for synthesizing high-value intermediates where the presence of fluorine atoms dramatically alters physical, chemical, and biological properties. It is a critical raw material for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, enabling the development of novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), including potential antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used to manufacture advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances efficacy and environmental stability.
• Fluorinated Material Building Block: Serves as a monomer or intermediate for creating specialty polymers, liquid crystals, and coatings with unique surface properties and chemical resistance.
• Organic Synthesis Reagent: Employed in Claisen condensations, Michael additions, and heterocyclic chemistry to construct complex, fluorinated organic molecules in R&D settings.
• Chemical Research & Development: A fundamental tool for medicinal and process chemists exploring structure-activity relationships (SAR) and novel synthetic pathways.

Basic Information

Product Name	Ethyl 2-Methyl-4,4,4-Trifluoroacetoacetate
CAS No.	344-00-3
Molecular Formula	C7H9F3O3
Molecular Weight	198.14 g/mol
Synonyms	Ethyl 2-Methyl-4,4,4-Trifluoro-3-oxobutanoate; 4,4,4-Trifluoro-2-methylacetoacetic Acid Ethyl Ester; 2-Methyl-4,4,4-trifluoroacetoacetic Acid Ethyl Ester; Ethyl 4,4,4-Trifluoroacetoacetate; Ethyl 2-Methyl-4,4,4-Trifluorobut-3-oxoate; TFAAE; Trifluoroacetoacetic Ester
EINECS	206-456-5

Quality Control

Our Ethyl 2-Methyl-4,4,4-Trifluoroacetoacetate is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place away from strong bases and incompatible materials. Due to its highly volatile nature, keep containers tightly sealed when not in use. Recommended storage temperature: 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.390 - 1.400
Density (20°C)	1.25 - 1.35 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.