Description

Methyl 3,3,3-Trifluoro-2-Methylpropanoate CAS NO 339-17-3 is a high-purity fluorinated ester building block, essential for introducing the trifluoromethyl group into complex molecular architectures. Its primary value lies in serving as a versatile synthon for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the CF3 moiety enhances metabolic stability and lipophilicity. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) containing trifluoromethyl groups, which are prevalent in modern drug discovery for oncology, CNS, and antiviral therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine atoms contribute to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, enhancing their dielectric anisotropy and stability.
• Polymer & Coating Modifiers: Incorporated to create specialty polymers with enhanced chemical resistance, lower surface energy, and improved weatherability for high-performance coatings.
• Organic Synthesis Reagent: A valuable reagent in academic and industrial research for nucleophilic trifluoromethylation and other fluorination reactions under mild conditions.

Basic Information

Product Name	Methyl 3,3,3-Trifluoro-2-Methylpropanoate
CAS No.	339-17-3
Molecular Formula	C5H7F3O2
Molecular Weight	156.10 g/mol
Synonyms	Methyl 3,3,3-Trifluoro-2-methylpropionate; 3,3,3-Trifluoro-2-methylpropionic Acid Methyl Ester; 2-Methyl-3,3,3-trifluoropropanoic Acid Methyl Ester; Methyl 2-Methyl-3,3,3-trifluoropropanoate; 3,3,3-Trifluoro-2-methylpropanoic Acid Methyl Ester; Methyl α-Methyl-β,β,β-trifluoropropionate; Propanoic acid, 3,3,3-trifluoro-2-methyl-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3,3,3-Trifluoro-2-Methylpropanoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure it meets the high-purity standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is sensitive to strong alkalis and fluorides; ensure segregation from incompatible substances. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%
Refractive Index (20°C)	1.350 - 1.360
Density (20°C)	1.20 - 1.30 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.