Description

L-Noradrenaline Hydrochloride is the hydrochloride salt of the naturally occurring catecholamine neurotransmitter and hormone, L-Norepinephrine. This high-purity active pharmaceutical ingredient (API) is critical for its potent vasoconstrictive and cardiac stimulant properties, making it essential for precise pharmacological formulations. It is primarily required by pharmaceutical manufacturers and research institutions for the production of emergency medications, advanced cardiovascular research, and as a key analytical reference standard.

Application

• Pharmaceutical API: Core ingredient in injectable formulations for the emergency treatment of acute hypotension, septic shock, and cardiac arrest.
• Biochemical Research: Essential tool in neuroscience and pharmacology studies investigating adrenergic receptor function, synaptic transmission, and autonomic nervous system regulation.
• Diagnostic Agent: Used in diagnostic tests and procedures to assess autonomic nervous system integrity and vascular responsiveness.
• Reference Standard: Serves as a high-purity calibrant and system suitability standard in analytical methods like HPLC and LC-MS for quality control laboratories.
• Veterinary Medicine: Employed in veterinary critical care for similar cardiovascular support applications in animals.

Basic Information

Product Name	L-Noradrenaline Hydrochloride
CAS No.	329-56-6
Molecular Formula	C8H11NO3 • HCl
Molecular Weight	205.64 g/mol
Synonyms	(-)-Norepinephrine Hydrochloride; L-Norepinephrine Hydrochloride; (R)-(-)-Norepinephrine Hydrochloride; Levarterenol Hydrochloride; Noradrenaline HCl; Arterenol Hydrochloride; 4-[(1R)-2-Amino-1-hydroxyethyl]benzene-1,2-diol hydrochloride; (R)-4-(2-Amino-1-hydroxyethyl)pyrocatechol hydrochloride
EINECS	206-347-0

Quality Control

Our L-Noradrenaline Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with pharmacopeial standards (e.g., USP, EP). A detailed Certificate of Analysis (COA) providing batch-specific results is supplied with every shipment to guarantee traceability and compliance for our customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under conditions of low humidity to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Specific Rotation	-37.0° to -41.0° (c = 2 in water)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.