Description

1-(Trimethylsilyl)-2-(Trifluoromethyl)Benzene is a high-value organosilicon and fluorinated aromatic compound, serving as a versatile building block in advanced organic synthesis. Its unique structure, combining a silyl protecting group with an electron-withdrawing trifluoromethyl moiety, makes it a critical reagent for introducing functional complexity into target molecules. This specialty chemical is essential for R&D and production chemists in the pharmaceutical, agrochemical, and materials science industries seeking to develop novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to desired electronic and optical properties.
• Advanced Polymer Chemistry: Employed as a monomer or modifier in the production of specialty polymers, including silicones and high-performance resins with specific thermal or chemical resistance.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to the reactivity of the silyl group, enabling complex biaryl formation.
• Protecting Group Strategy: The trimethylsilyl group can be used as a temporary protecting group for hydroxyl or other sensitive functionalities in multi-step synthetic pathways.

Basic Information

Item	Detail
Product Name	1-(Trimethylsilyl)-2-(Trifluoromethyl)Benzene
CAS No.	312-92-5
Molecular Formula	C10H13F3Si
Molecular Weight	218.29 g/mol
Synonyms	2-(Trifluoromethyl)phenyltrimethylsilane; (2-Trifluoromethylphenyl)trimethylsilane; α,α,α-Trifluoro-o-tolyltrimethylsilane; o-(Trimethylsilyl)benzotrifluoride; Trimethyl(2-(trifluoromethyl)phenyl)silane; Benzene, 1-(trimethylsilyl)-2-(trifluoromethyl)-; TMS-C6H4-CF3 (o-isomer)
EINECS	Contact for details

Quality Control

Our production of 1-(Trimethylsilyl)-2-(Trifluoromethyl)Benzene adheres to a stringent quality management system. Every batch is analyzed using advanced techniques including GC, HPLC, and NMR to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ISO 9001 standards for reliable integration into regulated synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.440 - 1.450
Density (g/mL at 20°C)	1.10 - 1.20

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.