Description

Hyoscyamine Hydrobromide is a high-purity alkaloid salt derived from plants of the Solanaceae family, serving as a critical active pharmaceutical ingredient (API). Its primary value lies in its potent anticholinergic and antispasmodic properties, which are essential for precise therapeutic applications. This compound is indispensable for pharmaceutical manufacturers and research institutions developing treatments for gastrointestinal disorders, ophthalmic solutions, and as a precursor in advanced drug synthesis.

Application

• Pharmaceutical API: Core active ingredient in antispasmodic and anticholinergic medications for treating gastrointestinal cramps, irritable bowel syndrome (IBS), and bladder spasms.
• Ophthalmic Solutions: Used in diagnostic and therapeutic eye drops to induce mydriasis (pupil dilation) for retinal examinations and surgical procedures.
• Analgesic Adjunct: Incorporated into formulations to relieve pain associated with smooth muscle spasms.
• Research & Development: Serves as a key reference standard and building block in pharmacological research, neuroscience studies, and the development of new anticholinergic agents.
• Veterinary Medicine: Employed in veterinary pharmaceuticals to manage colic and spasmodic conditions in animals.
• Controlled Drug Delivery Systems: Utilized in the development of transdermal patches and other sustained-release formulations.

Basic Information

Product Name	Hyoscyamine Hydrobromide
CAS No.	306-03-6
Molecular Formula	C17H23NO3 • HBr
Molecular Weight	370.28 g/mol
Synonyms	Atropine Hydrobromide (isomer); (-)-Hyoscyamine Hydrobromide; L-Hyoscyamine Hydrobromide; Daturine Hydrobromide; 3α-Tropanyl S-(-)-tropate hydrobromide; Tropine tropate hydrobromide; Endosyamine Hydrobromide; CAS 306-03-6
EINECS	206-180-6

Quality Control

Our Hyoscyamine Hydrobromide is manufactured under strict quality management systems. We offer material compliant with major pharmacopoeial standards, including USP and EP monographs. Every batch undergoes comprehensive analytical testing, including HPLC for assay and related substances, to ensure identity, purity, and potency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packing.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (Titration)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 1.0%
Specific Rotation	-20° to -23° (c = 5 in H2O)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.