Description

Chlorambucil is a nitrogen mustard alkylating agent and a critical active pharmaceutical ingredient (API) used in chemotherapy. Its primary value lies in its potent antineoplastic activity, making it a cornerstone in the treatment of specific hematological malignancies. This compound is essential for pharmaceutical manufacturers and research institutions developing and producing targeted cancer therapies, particularly for chronic lymphocytic leukemia (CLL) and Hodgkin's lymphoma.

Application

• Oncological Pharmaceutical Manufacturing: Primary use as the active pharmaceutical ingredient (API) in oral chemotherapy drugs for treating chronic lymphocytic leukemia (CLL) and Hodgkin's lymphoma.
• Clinical Research & Drug Development: Serves as a reference standard and a key intermediate in the R&D of new alkylating agents and combination cancer therapies.
• Biomedical Research: Utilized in in vitro and in vivo studies to investigate mechanisms of apoptosis, DNA cross-linking, and resistance in cancer cell lines.
• Veterinary Oncology: Applied in the formulation of chemotherapeutic treatments for certain cancers in animals.

Basic Information

Product Name	Chlorambucil
CAS No.	305-03-3
Molecular Formula	C14H19Cl2NO2
Molecular Weight	304.21 g/mol
Synonyms	4-[Bis(2-chloroethyl)amino]benzenebutanoic acid; Leukeran; Chloraminophene; CB-1348; NSC-3088; Linfolysin; Chlorbutin; Amboclorin
EINECS	206-162-9

Quality Control

Our Chlorambucil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and purity, identification by IR spectroscopy, and control of specified impurities. We provide full traceability and Certificates of Analysis (COA) compliant with current industry and regulatory standards to support your pharmaceutical development and manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.