Description

Pyridine, 2-[(4R)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]-4-(Trifluoromethyl)- is a high-value, chiral oxazoline-substituted pyridine derivative, serving as a sophisticated building block in advanced organic synthesis. Its core value lies in the combination of a stereogenic center, a trifluoromethyl group for modulating lipophilicity and metabolic stability, and a pyridine-oxazoline framework that can act as a ligand or a functional intermediate. This compound is critically needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery of novel active ingredients, particularly where precise stereochemistry and fluorine incorporation are required.

Application

• Pharmaceutical Intermediate: Key chiral precursor for synthesizing novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Building block for developing advanced pesticides and herbicides with enhanced activity and environmental profile.
• Catalyst Ligand Development: The oxazoline-pyridine moiety can be utilized in the design of asymmetric catalysts for enantioselective transformations.
• Material Science Research: Intermediate for creating functionalized organic molecules used in advanced materials, such as liquid crystals or organic semiconductors.
• Fluorine Chemistry Studies: Valuable compound for research into the structure-activity relationships imparted by the trifluoromethyl group.
• Custom Synthesis & Contract Manufacturing: Sourced by CDMOs for the production of bespoke molecules for client R&D programs.

Basic Information

Product Name	Pyridine, 2-[(4R)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]-4-(Trifluoromethyl)-
CAS No.	2828432-07-9
Molecular Formula	C14H17F3N2O
Molecular Weight	286.30 g/mol
Synonyms	(R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)-2-[(4R)-4-(tert-butyl)-4,5-dihydro-1,3-oxazol-2-yl]pyridine; (R)-4-(tert-Butyl)-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole; 2-[(4R)-4-(tert-Butyl)-4,5-dihydro-2-oxazolyl]-4-(trifluoromethyl)pyridine; Chiral Oxazoline-Pyridine Derivative; tert-Butyl Oxazoline Pyridine Trifluoromethyl Compound
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high chiral purity, which is critical for downstream synthesis. Quality is verified through comprehensive analytical methods including HPLC, chiral HPLC, GC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, enantiomeric excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.