Description

Pyridine, 2-[(4R)-4,5-Dihydro-4-(1-Methylethyl)-2-Oxazolyl]-4-(Trifluoromethyl)- is a specialized chiral oxazoline-substituted pyridine derivative, serving as a high-value building block in advanced organic synthesis. Its molecular architecture, featuring a trifluoromethyl group and a stereodefined oxazoline ring, makes it a critical intermediate for constructing complex molecules with precise spatial orientation. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is utilized to develop novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group and chiral center can improve biological activity and environmental stability.
• Ligand Precursor in Catalysis: The oxazoline moiety can be further functionalized to create chiral ligands for asymmetric catalysis, enabling more efficient and selective chemical transformations.
• Material Science Research: Investigated as a functional component in the synthesis of specialty polymers, liquid crystals, or organic electronic materials due to its unique electronic properties.
• Chemical Biology Probes: Serves as a scaffold for developing molecular probes and diagnostic agents in biochemical research.

Basic Information

Item	Details
Product Name	Pyridine, 2-[(4R)-4,5-Dihydro-4-(1-Methylethyl)-2-Oxazolyl]-4-(Trifluoromethyl)-
CAS No.	2828432-06-8
Molecular Formula	C12H13F3N2O
Molecular Weight	258.24 g/mol
Synonyms	2-[(4R)-4,5-Dihydro-4-Isopropyl-2-Oxazolyl]-4-(Trifluoromethyl)Pyridine; (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)-2-[(4R)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl]pyridine; (R)-4,5-Dihydro-4-(1-methylethyl)-2-[4-(trifluoromethyl)-2-pyridinyl]-Oxazole; Chiral Trifluoromethyl Pyridine-Oxazoline Derivative
EINECS	Contact for details

Quality Control

Our Pyridine, 2-[(4R)-4,5-Dihydro-4-(1-Methylethyl)-2-Oxazolyl]-4-(Trifluoromethyl)- is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its fluoride/strong alkali-related properties, keep away from incompatible materials such as strong acids and oxidizing agents. For long-term storage, consider using an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.