Description

5-Nitro-Spiro[Indoline-3,4'-Piperidin]-2-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic molecular architecture. This compound is of significant value in medicinal chemistry for its role as a key building block in the research and development of novel therapeutic agents. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in synthesizing innovative drug candidates, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting complex biological pathways.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Employed in pharmacological assays and as a reference standard to study specific enzyme or receptor interactions.
• Academic & Institutional R&D: Utilized in university and research institute laboratories for exploratory synthetic chemistry and the development of new synthetic methodologies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.

Basic Information

Product Name	5-Nitro-Spiro[Indoline-3,4'-Piperidin]-2-One Hydrochloride
CAS No.	2803477-01-0
Molecular Formula	C13H14N3O3·HCl
Molecular Weight	297.73 g/mol (Free base: 260.27 g/mol)
Synonyms	5-Nitro-spiro[indoline-3,4'-piperidin]-2-one hydrochloride; 5-Nitro-2-oxospiro[indoline-3,4'-piperidine] hydrochloride; 2H-Spiro[indole-3,4'-piperidin]-2-one, 5-nitro-, hydrochloride (1:1); 5-Nitro-1'H-spiro[indoline-3,4'-piperidin]-2-one hydrochloride; 2803477-01-0; 5-Nitro-spiro[indoline-3,4'-piperidine]-2-one HCl; 5-Nitro-2-oxo-1'H-spiro[indoline-3,4'-piperidine] hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 5-Nitro-Spiro[Indoline-3,4'-Piperidin]-2-One Hydrochloride is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.