Description

Pyrimidine, 2-[(4R)-4,5-Dihydro-4-(1-Methylethyl)-2-Oxazolyl]- is a specialized chiral heterocyclic compound featuring a pyrimidine core fused with a substituted oxazoline ring. This molecular architecture makes it a high-value intermediate for the synthesis of complex bioactive molecules. It is primarily sought after by pharmaceutical R&D and fine chemical synthesis teams for developing new therapeutic agents and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and neurological drug discovery.
• Asymmetric Synthesis: Utilized as a chiral ligand or auxiliary in catalytic asymmetric reactions to produce enantiomerically pure compounds.
• Agrochemical Research: Intermediate in the development of new generation herbicides, fungicides, and plant growth regulators.
• Material Science: Precursor for creating specialized polymers, liquid crystals, or organic electronic materials with tailored properties.
• Academic & Contract Research: Used in university and CRO laboratories for methodological development and exploring new chemical spaces.

Basic Information

Item	Details
Product Name	Pyrimidine, 2-[(4R)-4,5-Dihydro-4-(1-Methylethyl)-2-Oxazolyl]-
CAS No.	2757082-66-7
Molecular Formula	C10H13N3O
Molecular Weight	191.23 g/mol
Synonyms	2-[(4R)-4,5-Dihydro-4-isopropyl-2-oxazolyl]pyrimidine; (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)pyrimidine; (4R)-4-Isopropyl-2-(pyrimidin-2-yl)-4,5-dihydro-1,3-oxazole; 2-[(4R)-4-Isopropyl-2-oxazolin-2-yl]pyrimidine; Chiral Oxazoline-Pyrimidine Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested to ensure identity, purity, and enantiomeric excess meet the high standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from HPLC, NMR, and chiral analysis. We support development with custom synthesis and scale-up under cGMP guidelines as needed.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat and incompatible materials. For long-term storage, consider an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.