Description

Pyridine, 2-[(4R)-4,5-Dihydro-4-(1-Methylethyl)-2-Oxazolyl]-6-Phenyl- is a high-purity, chiral oxazoline-substituted pyridine derivative, serving as a sophisticated building block in advanced organic synthesis. Its value lies in its role as a key ligand precursor or intermediate for the development of asymmetric catalysts and active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require structurally complex and enantiomerically pure intermediates.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel, chiral drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Asymmetric Catalyst Ligand: Serves as a precursor for chiral ligands used in transition metal catalysis (e.g., palladium, rhodium, iridium) to induce enantioselectivity in C-H activation, hydrogenation, and cross-coupling reactions.
• Agrochemical Research: Intermediate in the development of new-generation, enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science: Used in the synthesis of functionalized organic molecules for advanced materials, including liquid crystals and organic semiconductors.
• Academic & Contract Research: A valuable tool for methodology development in academic laboratories and contract research organizations (CROs) focused on stereoselective synthesis.

Basic Information

Product Name	Pyridine, 2-[(4R)-4,5-Dihydro-4-(1-Methylethyl)-2-Oxazolyl]-6-Phenyl-
CAS No.	2757082-65-6
Molecular Formula	C₁₇H₁₈N₂O
Molecular Weight	266.34 g/mol
Synonyms	2-[(4R)-4,5-Dihydro-4-isopropyl-2-oxazolyl]-6-phenylpyridine; (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)-6-phenylpyridine; (R)-4-Isopropyl-2-(6-phenylpyridin-2-yl)-4,5-dihydrooxazole; 6-Phenyl-2-[(4R)-4-(propan-2-yl)-4,5-dihydro-1,3-oxazol-2-yl]pyridine; Chiral Oxazoline-Pyridine Ligand Precursor; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality control protocols to ensure identity, purity, and enantiomeric excess meet the exacting standards of process chemistry and research. Our rigorous analytical testing includes HPLC, chiral HPLC, NMR, and MS to verify specifications. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.