Description

Pyridine, 2-[(4R,5R)-4,5-Dihydro-4,5-Diphenyl-2-Oxazolyl]-6-Phenyl- is a specialized chiral oxazoline-substituted pyridine derivative, serving as a high-value building block and ligand in advanced chemical synthesis. Its precise stereochemistry and unique heterocyclic structure make it a critical component for developing enantioselective catalysts and novel pharmaceutical intermediates. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical sectors who require sophisticated chiral auxiliaries for asymmetric synthesis.

Application

• Asymmetric Catalysis: Acts as a chiral ligand for transition metal catalysts in enantioselective C-C and C-X bond-forming reactions.
• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) with defined stereocenters.
• Agrochemical Research: Used in the development of novel, chiral pesticides and herbicides with improved efficacy and selectivity.
• Fine Chemical Synthesis: Employed as a building block for complex natural products, flavors, and fragrances requiring high optical purity.
• Material Science: Investigated for the creation of chiral polymers and advanced functional materials with specific optical properties.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and process chemistry laboratories.

Basic Information

Product Name	Pyridine, 2-[(4R,5R)-4,5-Dihydro-4,5-Diphenyl-2-Oxazolyl]-6-Phenyl-
CAS No.	2757082-61-2
Molecular Formula	C26H20N2O
Molecular Weight	376.45 g/mol
Synonyms	(4R,5R)-4,5-Dihydro-2-(6-phenylpyridin-2-yl)-4,5-diphenyloxazole; 2-[(4R,5R)-4,5-Dihydro-4,5-diphenyl-1,3-oxazol-2-yl]-6-phenylpyridine; (R,R)-2-(6-Phenylpyridin-2-yl)-4,5-diphenyl-4,5-dihydrooxazole; Chiral Pyridine-Oxazoline Ligand; (R,R)-PyOx Ligand; (R,R)-PHOX Derivative; (4R,5R)-2-(6-Phenyl-2-pyridyl)-4,5-diphenyl-2-oxazoline
EINECS	Contact for details

Quality Control

Our production of Pyridine, 2-[(4R,5R)-4,5-Dihydro-4,5-Diphenyl-2-Oxazolyl]-6-Phenyl- adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is characterized by advanced analytical techniques, including chiral HPLC and NMR spectroscopy, to confirm identity, enantiomeric excess (ee), and chemical purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP and ISO 9001 compliant manufacturing for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). For long-term storage, consider inert atmosphere conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.