Description

Pyridine, 2-[(4S,5S)-4,5-Dihydro-4,5-Diphenyl-2-Oxazolyl]-6-Phenyl- is a high-purity, chiral oxazoline-substituted pyridine derivative. This compound serves as a sophisticated ligand precursor and organocatalyst in advanced synthetic chemistry, enabling precise stereochemical control. It is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries developing novel active ingredients and complex molecules.

Application

• Asymmetric Catalysis: A key chiral ligand for transition metal-catalyzed reactions, including enantioselective hydrogenation, cross-coupling, and cyclopropanation.
• Pharmaceutical Intermediates: Critical building block in the synthesis of chiral active pharmaceutical ingredients (APIs) and complex drug candidates.
• Organocatalysis: Functions as a catalyst or catalyst precursor in metal-free, enantioselective organic transformations.
• Material Science Research: Used in the development of chiral functional materials and advanced polymers with specific optical properties.
• Agrochemical Synthesis: Intermediate for creating enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & R&D: A valuable tool for methodological development in synthetic organic chemistry laboratories worldwide.

Basic Information

Product Name	Pyridine, 2-[(4S,5S)-4,5-Dihydro-4,5-Diphenyl-2-Oxazolyl]-6-Phenyl-
CAS No.	2757082-57-6
Molecular Formula	C26H20N2O
Molecular Weight	376.45 g/mol
Synonyms	(4S,5S)-4,5-Dihydro-2-(6-phenylpyridin-2-yl)-4,5-diphenyloxazole; (S,S)-2-(6-Phenylpyridin-2-yl)-4,5-dihydro-4,5-diphenyloxazole; Chiral Pyridine-Oxazoline Ligand; (S,S)-PyOx Ligand; (S,S)-2-(6-Phenyl-2-pyridyl)-4,5-dihydro-4,5-diphenyloxazole; (4S,5S)-2-(6-Phenyl-2-pyridinyl)-4,5-diphenyl-4,5-dihydrooxazole; (S,S)-PHOX-type ligand derivative; 2-[(4S,5S)-4,5-Dihydro-4,5-diphenyl-2-oxazolyl]-6-phenylpyridine
EINECS	Contact for details

Quality Control

Our production of this chiral chemical adheres to stringent quality protocols. Every batch is characterized and tested to ensure high enantiomeric purity and chemical identity, meeting the exacting standards required for catalysis and pharmaceutical R&D. Comprehensive analytical data, including HPLC for chiral purity and NMR for structural confirmation, is documented. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.