Description

Pyridine, 2-[(4R)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]-6-Phenyl- is a high-purity, chiral oxazoline-substituted pyridine derivative, serving as a sophisticated building block and ligand in advanced organic synthesis. Its value lies in its ability to impart stereoselectivity and modulate reactivity in catalytic processes, enabling the production of complex, optically active molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who are developing novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral targets.
• Asymmetric Catalysis Ligand: Used as a chiral ligand for transition metal catalysts (e.g., with copper, palladium) to enable enantioselective C-H activation, cycloaddition, or cross-coupling reactions.
• Agrochemical Synthesis: Employed in the research and development of advanced, stereospecific herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Serves as a critical scaffold for creating specialty chemicals, flavors, fragrances, and advanced materials requiring specific chiral configurations.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and medicinal chemistry programs focused on stereocontrol.

Basic Information

Product Name	Pyridine, 2-[(4R)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]-6-Phenyl-
CAS No.	2757082-55-4
Molecular Formula	C21H20N2O
Molecular Weight	316.40 g/mol
Synonyms	(R)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)-6-phenylpyridine; (4R)-4-Benzyl-2-(6-phenyl-2-pyridinyl)-4,5-dihydro-1,3-oxazole; 2-[(4R)-4-Benzyl-4,5-dihydro-1,3-oxazol-2-yl]-6-phenylpyridine; (R)-4-Benzyl-2-(6-phenylpyridin-2-yl)-4,5-dihydrooxazole; Chiral Pyridine-Oxazoline Ligand; (R)-PyOx Ligand Derivative; 2-(4,5-Dihydro-4-(phenylmethyl)-2-oxazolyl)-6-phenylpyridine, (4R)-
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Every lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), enantiomeric excess (ee), and impurity profile is provided with each shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.