Description

5-Bromo-2-(2,6-Dioxopiperidin-3-Yl)-4-Fluoroisoindoline-1,3-Dione is a high-purity, advanced pharmaceutical intermediate designed for research and development in modern drug discovery. This compound is of significant interest for its role as a key building block in the synthesis of targeted protein degradation therapeutics, such as Proteolysis Targeting Chimeras (PROTACs) and molecular glues. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on oncology, neurodegenerative diseases, and other areas requiring novel therapeutic modalities.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel small-molecule drugs, particularly those employing targeted protein degradation mechanisms.
• PROTAC Development: Serves as a core component for constructing the cereblon (CRBN)-binding ligand (or "warhead") segment of bifunctional PROTAC molecules.
• Molecular Glue Research: Used in the discovery and optimization of molecular glues that induce neo-protein-protein interactions for therapeutic benefit.
• Chemical Biology Probes: Employed in the creation of tool compounds to study E3 ubiquitin ligase function and substrate degradation pathways.
• Oncology Drug Discovery: Integral to R&D programs aimed at developing next-generation cancer therapies that target previously "undruggable" proteins.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and pilot-scale synthesis for clinical candidate molecules.

Basic Information

Product Name	5-Bromo-2-(2,6-Dioxopiperidin-3-Yl)-4-Fluoroisoindoline-1,3-Dione
CAS No.	2740657-28-5
Molecular Formula	C₁₃H₉BrFN₃O₄
Molecular Weight	370.13 g/mol
Synonyms	5-Bromo-4-fluoro-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 5-Bromo-4-fluoro-2-(2,6-dioxo-3-piperidyl)isoindole-1,3-dione; 5-Bromo-4-fluoro-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione; 5-Bromo-4-fluoro-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 5-Bromo-4-fluoro-2-(2,6-dioxopiperidin-3-yl)phthalimide; PROTAC Cereblon Ligand Derivative; CRBN Ligand Intermediate; Thalidomide Derivative Intermediate
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(2,6-Dioxopiperidin-3-Yl)-4-Fluoroisoindoline-1,3-Dione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.