Description

Azido-Peg2-C6-Cl is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group and a chloro terminal, connected by a hexyl spacer. This compound is a critical reagent for click chemistry, enabling the efficient and bioorthogonal conjugation of biomolecules, polymers, and surfaces. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotech, and materials science industries for applications such as antibody-drug conjugate (ADC) development, surface functionalization, and polymer modification.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key component for constructing stable, cleavable linkers between cytotoxic payloads and monoclonal antibodies.
• Bioconjugation & Labeling: Facilitates the site-specific labeling of proteins, peptides, and oligonucleotides via copper-free or copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Polymer & Materials Functionalization: Used to introduce reactive azide groups into polymer backbones or material surfaces for subsequent modification.
• Surface Chemistry & Immobilization: Enables the covalent attachment of biomolecules to chips, beads, and other solid supports for biosensor and diagnostic assay development.
• Crosslinking Agent: Acts as a versatile crosslinker for creating hydrogels or modifying biomaterial properties.
• Prodrug Synthesis: Employed in the design of prodrugs where a therapeutic agent is released upon specific biological triggers.
• Chemical Biology Probes: Integral for synthesizing activity-based probes to study enzyme function and protein interactions.
• Nanoparticle Modification: Used to functionalize liposomes, dendrimers, and other nanoparticles for targeted drug delivery systems.

Basic Information

Product Name	Azido-Peg2-C6-Cl
CAS No.	2568146-55-2
Molecular Formula	C₁₄H₂₇ClN₃O₄
Molecular Weight	336.83 g/mol
Synonyms	6-Azido-2,5,8,11-tetraoxatetradecan-14-oyl chloride; 1-Azido-3,6,9-trioxa-12-azatetradecan-14-oyl chloride; Azido-PEG2-C6-acid chloride; N-(Azido-PEG2)-6-aminohexanoyl chloride; Azido-PEG2-C6 acid chloride; Azido-(CH2)6-PEG2-Cl; Heterobifunctional PEG linker, Azide/Chloro; PEG-based crosslinker, Azide terminated
EINECS	Contact for details

Quality Control

Our Azido-Peg2-C6-Cl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. We provide comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles to ensure compliance with research and cGMP-grade material standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. The product is moisture-sensitive and should be handled under inert atmosphere (argon or nitrogen) when possible to maintain reactivity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.