Description

(3R)-4,4-Difluoro-3-Methyl-Piperidine Hydrochloride is a high-purity, chiral piperidine derivative of significant interest in advanced pharmaceutical synthesis. This compound serves as a critical building block for the development of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas. It is essential for medicinal chemistry research, process development, and scale-up manufacturing within the pharmaceutical and biotechnology industries, where precise stereochemistry and fluorine substitution are key design elements.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for CNS-targeting therapies.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique difluoro-methyl piperidine scaffold.
• API Synthesis: Incorporated into the synthetic route of complex molecules requiring a stereochemically defined, fluorinated piperidine moiety.
• Preclinical & Clinical Development: Serves as a critical raw material for producing compounds for toxicology studies and clinical trial materials (CTM).
• Chemical Biology Probes: Utilized in the design of tool compounds for investigating biological pathways and target validation.
• Agrochemical Research: Potential application in the synthesis of novel crop protection agents with enhanced properties.

Basic Information

Product Name	(3R)-4,4-Difluoro-3-Methyl-Piperidine Hydrochloride
CAS No.	2503325-78-6
Molecular Formula	C6H12ClF2N
Molecular Weight	171.62 g/mol
Synonyms	(3R)-4,4-Difluoro-3-methylpiperidine hydrochloride; (R)-4,4-Difluoro-3-methylpiperidine HCl; 4,4-Difluoro-3-methylpiperidine hydrochloride, (3R)-; 2503325-78-6; (R)-3-Methyl-4,4-difluoropiperidine hydrochloride; 4,4-Difluoro-3(R)-methylpiperidine hydrochloride; (3R)-3-Methyl-4,4-difluoropiperidinium chloride
EINECS	Contact for details

Quality Control

Our (3R)-4,4-Difluoro-3-Methyl-Piperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.