Description

Spiro[3H-Indole-3,4'-[4H]Pyran]-2(1H)-One, 5-Bromo-2',3',5',6'-Tetrahydro-1-Methyl- is a high-value, complex spirocyclic indole derivative, serving as a critical synthetic intermediate for advanced pharmaceutical research and development. Its unique molecular architecture, featuring a fused indole and tetrahydropyran ring system, makes it an essential building block for constructing novel bioactive molecules. This compound is primarily utilized by medicinal chemists and R&D departments in the pharmaceutical, agrochemical, and fine chemical industries for the discovery of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in high-throughput screening campaigns.
• Agrochemical Development: Serves as a building block for creating new active ingredients with potential herbicidal or insecticidal properties.
• Organic Synthesis: Employed in academic and industrial laboratories for methodological development and the construction of complex heterocyclic compounds.
• Chemical Biology Probes: Utilized in the development of molecular probes to study biological pathways and protein functions.

Basic Information

Product Name	Spiro[3H-Indole-3,4'-[4H]Pyran]-2(1H)-One, 5-Bromo-2',3',5',6'-Tetrahydro-1-Methyl-
CAS No.	2491753-71-8
Molecular Formula	C16H16BrNO2
Molecular Weight	334.21 g/mol
Synonyms	5-Bromo-1-methyl-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one; 5-Bromo-1-methyl-2,3,5,6-tetrahydrospiro[4H-1-benzopyran-4,3'-indoline]-2'-one; 5-Bromo-1-methyl-2,3,5,6-tetrahydrospiro[chromene-4,3'-indolin]-2'-one; 2491753-71-8; Spiro[indoline-3,4'-pyran]-2-one, 5-bromo-2',3',5',6'-tetrahydro-1-methyl-; 1-Methyl-5-bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one
EINECS	Contact for details

Quality Control

Our Spiro[3H-Indole-3,4'-[4H]Pyran]-2(1H)-One, 5-Bromo-2',3',5',6'-Tetrahydro-1-Methyl- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.