Description

Mpeg10-Nhs Ester CAS NO 2490419-63-9 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a methoxy-terminated PEG chain (mPEG) and an N-hydroxysuccinimide (NHS) ester reactive group. This compound is engineered to facilitate the site-specific conjugation of biomolecules, such as peptides, proteins, and antibodies, to PEG chains, a process known as PEGylation. It is an essential reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise and stable modification of therapeutic agents to enhance their solubility, stability, and pharmacokinetic profiles.

Application

• Pharmaceutical PEGylation: Conjugation to amine groups on therapeutic proteins, peptides, and antibodies to improve circulatory half-life and reduce immunogenicity.
• Bioconjugation & Linker Chemistry: Serving as a heterobifunctional crosslinker for creating stable amide bonds between PEG polymers and biomolecules in diagnostic assay development.
• Drug Delivery System Development: Functionalizing nanoparticles, liposomes, and other drug carriers with stealth PEG layers to enhance targeting and reduce clearance.
• Biomaterial Surface Modification: Grafting PEG brushes onto medical device surfaces or scaffolds to create non-fouling, biocompatible interfaces.
• ADC (Antibody-Drug Conjugate) Payload Attachment: Facilitating the controlled attachment of cytotoxic drugs or imaging agents to targeting antibodies via cleavable or non-cleavable linkers.
• Research & Process Development: Used in R&D laboratories for proof-of-concept studies and process optimization for new biologic entities.

Basic Information

Product Name	Mpeg10-Nhs Ester
CAS No.	2490419-63-9
Molecular Formula	CnH2n+2O11 * (Exact formula varies by PEG chain length distribution)
Molecular Weight	~ 600 g/mol (Average MW for n=10)
Synonyms	mPEG10-NHS Ester; Methoxy PEG10 NHS Ester; α-Methoxy-ω-succinimidyl ester of decaethylene glycol; NHS-PEG10-OMe; N-Hydroxysuccinimide ester of monomethoxy polyethylene glycol (n=10); Succinimidyl ester of mPEG10; PEG10 spacer NHS ester; 2,5-Dioxopyrrolidin-1-yl 2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl carbonate
EINECS	Contact for details

Quality Control

Our Mpeg10-Nhs Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent functionality, and compliance with research and GMP-grade standards where applicable. Certificates of Analysis (COA) are provided, detailing key parameters such as assay purity, functional group substitution, and impurity profiles. We support our clients' regulatory needs with comprehensive documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and hydrolysis of the active NHS ester group.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (NMR/HPLC)	≥ 95%
Functional Substitution (NHS Ester)	≥ 90%
PEG Average Molecular Weight (n)	9 - 11 (n=10 nominal)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.