Description

1,2-Piperidinedicarboxylic Acid, 5-Hydroxy-, 1-(9H-Fluoren-9-Ylmethyl) Ester, (2S,5R)- is a high-purity, stereochemically defined chiral building block of significant interest in advanced pharmaceutical synthesis. This compound is specifically engineered to serve as a key intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly for complex therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in peptide mimetics, prodrug development, and targeted drug discovery programs requiring precise molecular architecture.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of complex drug candidates and novel APIs.
• Peptidomimetic Research: Used in constructing constrained peptide analogs and scaffolds for drug discovery targeting proteases and receptors.
• Prodrug Development: Serves as a protected precursor molecule that can be selectively cleaved to release active drug compounds in vivo.
• Asymmetric Synthesis: Employed in stereoselective chemical reactions to introduce the (2S,5R) configuration into target molecules.
• Chemical Biology Probes: Utilized in the development of labeled or tagged compounds for studying biological pathways and mechanisms.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring high chemical and optical purity.

Basic Information

Item	Detail
Product Name	1,2-Piperidinedicarboxylic Acid, 5-Hydroxy-, 1-(9H-Fluoren-9-Ylmethyl) Ester, (2S,5R)-
CAS No.	2453297-07-7
Molecular Formula	C23H23NO5
Molecular Weight	393.44 g/mol
Synonyms	(2S,5R)-5-Hydroxypiperidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester; Fmoc-protected hydroxyproline derivative; (2S,5R)-1-Fmoc-5-hydroxy-1,2-piperidinedicarboxylic acid; 1-(9H-Fluoren-9-ylmethyl) (2S,5R)-5-hydroxy-1,2-piperidinedicarboxylate; Fmoc-Hyp derivative; Chiral piperidine-Fmoc ester; 2453297-07-7; (2S,5R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-hydroxypiperidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical research and development. Quality is verified through comprehensive analytical techniques including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting specifications for identity, assay, chiral purity, and impurity profiles. We support compliance with cGMP guidelines for pharmaceutical starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.