Description

Pomalidomide 4'-Alkylc8-Amine CAS NO 2446474-06-0 is a high-purity, advanced pharmaceutical intermediate designed for targeted drug development. This compound is critical for researchers and manufacturers focused on creating next-generation immunomodulatory drugs and proteolysis-targeting chimeras (PROTACs). It is primarily utilized by pharmaceutical R&D teams and fine chemical suppliers engaged in the synthesis of novel therapeutic agents for oncology and autoimmune diseases.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel pomalidomide analogs and derivatives for clinical research.
• PROTAC Development: Serves as a critical linker component in the design and construction of proteolysis-targeting chimeras for targeted protein degradation.
• Immunomodulatory Drug Research: Used in the development of Cereblon (CRBN)-modulating agents for potential applications in hematology and oncology.
• Preclinical Candidate Synthesis: Essential for medicinal chemistry programs aiming to optimize drug-like properties such as potency, selectivity, and pharmacokinetics.
• Chemical Biology Tool: Employed in academic and industrial labs to study E3 ubiquitin ligase recruitment and substrate degradation mechanisms.
• GMP Starting Material: Suitable for use as a controlled intermediate in the cGMP manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Pomalidomide 4'-Alkylc8-Amine
CAS No.	2446474-06-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	4'-Aminoalkyl-pomalidomide C8 derivative; 4'-(8-Aminoalkyl)pomalidomide; Pomalidomide-4'-C8-amine; Pomalidomide alkylamine linker; CC-4047 derivative; (S)-3-(4-((8-Aminoalkyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivative; IMiD linker amine
EINECS	Contact for details

Quality Control

Our Pomalidomide 4'-Alkylc8-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with internal specifications and research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.