Description

3-(7-Bromo-4-Fluoro-1-Oxoisoindolin-2-Yl)Piperidine-2,6-Dione is a high-purity, advanced pharmaceutical intermediate designed for research and development in novel therapeutic agents. This compound is critical for medicinal chemists and process development scientists working on targeted protein degradation and other innovative drug discovery platforms. It is primarily utilized in the synthesis of complex small molecules for oncology, immunology, and neurology research, offering a reliable building block for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• PROTAC & Molecular Glue Development: Serves as a crucial component for constructing proteolysis-targeting chimeras (PROTACs) and other targeted protein degraders.
• Oncology Drug Discovery: Used in the synthesis of investigational compounds targeting various cancer pathways and protein-protein interactions.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and lead optimization campaigns in academic and industrial R&D labs.
• Process Chemistry & Scale-Up: Provides a defined starting material for route scouting, optimization, and pilot-scale manufacturing of clinical candidates.
• Bioconjugation & Chemical Biology: Can be utilized for labeling studies or as a handle for creating chemical probes to study biological systems.

Basic Information

Product Name	3-(7-Bromo-4-Fluoro-1-Oxoisoindolin-2-Yl)Piperidine-2,6-Dione
CAS No.	2438243-28-6
Molecular Formula	C13H10BrFN2O3
Molecular Weight	341.14 g/mol
Synonyms	7-Bromo-4-fluoro-2-(2,6-dioxopiperidin-3-yl)isoindolin-1-one; 2,6-Dioxopiperidin-3-yl 7-Bromo-4-fluoro-1-oxoisoindoline-2-carboxylate (tautomer); 3-(7-Bromo-4-fluoro-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione; 2438243-28-6; (7-Bromo-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; BRD4 Inhibitor Intermediate; PROTAC Building Block
EINECS	Contact for details

Quality Control

Our 3-(7-Bromo-4-Fluoro-1-Oxoisoindolin-2-Yl)Piperidine-2,6-Dione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH Q7 guidelines for active pharmaceutical ingredients, and our quality protocols are designed to support regulatory filings. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions or an inert atmosphere to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.