Description

2,7-Diazaspiro[3.5]Nonane-2-Carboxylic Acid, 7-(2-Propyn-1-Yl)-, 1,1-Dimethylethyl Ester is a high-value, spirocyclic building block featuring a protected carboxylic acid and a reactive alkyne moiety. This compound is specifically engineered for advanced pharmaceutical research and development, serving as a key intermediate in the synthesis of complex bioactive molecules. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical and biotechnology sectors for constructing novel drug candidates, particularly in targeted therapies.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery.
• PROTAC (Proteolysis Targeting Chimera) Development: Utilized in constructing linker-warhead conjugates due to its spirocyclic scaffold and alkyne handle for click chemistry.
• Peptidomimetic Chemistry: The diazaspiro structure serves as a rigid, three-dimensional scaffold to mimic peptide secondary structures and improve metabolic stability.
• Bioconjugation: The alkyne group enables efficient, site-specific conjugation to azide-functionalized biomolecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Chemical Biology Probe Synthesis: Used to create tool compounds for target identification and validation in biological pathways.
• Library Synthesis for High-Throughput Screening (HTS): Employed in generating diverse compound libraries to explore new chemical space in drug discovery campaigns.

Basic Information

Product Name	2,7-Diazaspiro[3.5]Nonane-2-Carboxylic Acid, 7-(2-Propyn-1-Yl)-, 1,1-Dimethylethyl Ester
CAS No.	2434850-33-4
Molecular Formula	C15H22N2O2
Molecular Weight	262.35 g/mol
Synonyms	tert-Butyl 7-(prop-2-yn-1-yl)-2,7-diazaspiro[3.5]nonane-2-carboxylate; 2,7-Diazaspiro[3.5]nonane-2-carboxylic acid, 7-(2-propyn-1-yl)-, 1,1-dimethylethyl ester; 2-(tert-Butoxycarbonyl)-2,7-diazaspiro[3.5]nonane-7-prop-2-yne; Boc-2,7-diazaspiro[3.5]nonane-7-prop-2-yne; 7-Propargyl-2-Boc-2,7-diazaspiro[3.5]nonane; Spirocyclic Boc-protected diaza-alkyne
EINECS	Contact for details

Quality Control

Our 2,7-Diazaspiro[3.5]Nonane-2-Carboxylic Acid, 7-(2-Propyn-1-Yl)-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.