Description

Azido-DPEG-OH is a functionalized polyethylene glycol derivative featuring a reactive azide group and a terminal hydroxyl group. This bifunctional linker is essential for creating stable, biocompatible conjugates in advanced material science and bioconjugation applications. It is particularly valuable for researchers and manufacturers in the pharmaceutical, diagnostics, and biomaterials sectors who require precise and reliable PEGylation reagents.

Application

• Bioconjugation and Click Chemistry: Utilized as a heterobifunctional crosslinker for coupling biomolecules (e.g., proteins, peptides, oligonucleotides) via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (SPAAC) reactions.
• PEGylation Reagent: Serves as a key intermediate for modifying therapeutic proteins, peptides, and nanoparticles to enhance solubility, stability, and circulation half-life.
• Polymer and Hydrogel Synthesis: Acts as a functional monomer or crosslinking agent in the development of smart hydrogels and functional polymers for drug delivery systems.
• Diagnostic Probe Development: Used to label antibodies, enzymes, or other detection molecules with fluorescent dyes or other reporter groups for diagnostic assays.
• Surface Functionalization: Enables the modification of material surfaces (e.g., gold nanoparticles, chips, beads) with bioactive molecules for biosensor and microarray applications.
• ADC (Antibody-Drug Conjugate) Linker Precursor: Provides a versatile scaffold for constructing cleavable or non-cleavable linkers in targeted cancer therapies.

Basic Information

Product Name	Azido-DPEG-OH
CAS No.	2415674-94-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Azido-PEG-OH; N3-PEG-OH; ω-Azido-ω-hydroxy poly(ethylene glycol); Azido-terminated polyethylene glycol monomethyl ether; PEG-Azide; Azido-PEG-alcohol; Heterobifunctional PEG azide; Poly(ethylene glycol) methyl ether azide
EINECS	Contact for details

Quality Control

Our Azido-DPEG-OH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and functional group analysis, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. For long-term storage under inert atmosphere, consider sealing under argon or nitrogen. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Average Molecular Weight	As per customer grade (e.g., 1kDa, 2kDa, 5kDa)
Azide Content (Titration)	≥ 90% of theoretical
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.