Description

Thalidomide-o-Amido-Peg4-Azide (CAS No. 2411681-89-3) is a specialized bifunctional linker molecule designed for advanced bioconjugation and PROTAC (Proteolysis Targeting Chimera) development. This compound integrates the cereblon (CRBN)-binding thalidomide moiety with a tetraethylene glycol (PEG4) spacer and a terminal azide group, enabling precise, click chemistry-based attachment to biomolecules. It is essential for researchers and developers in pharmaceutical R&D and biotechnology who require high-purity, functionalized intermediates for constructing targeted protein degraders, antibody-drug conjugates (ADCs), and other sophisticated therapeutic modalities.

Application

• PROTAC & Molecular Glue Development: Serves as a critical building block for synthesizing heterobifunctional degraders that recruit E3 ubiquitin ligases to target specific proteins for degradation.
• Antibody-Drug Conjugate (ADC) Payload Linkage: The terminal azide enables efficient, site-specific conjugation via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC) to alkynylated antibodies or proteins.
• Chemical Biology & Probe Design: Used to create activity-based probes for studying cereblon-dependent protein degradation pathways and target engagement.
• Biomaterial Functionalization: Facilitates the surface modification of nanoparticles, polymers, and hydrogels with thalidomide-derived ligands for targeted drug delivery systems.
• Precision Medicine Research: Enables the development of novel therapeutic agents for oncology, immunology, and neurodegenerative diseases by leveraging targeted protein degradation.

Basic Information

Product Name	Thalidomide-o-Amido-Peg4-Azide
CAS No.	2411681-89-3
Molecular Formula	C29H36N6O10
Molecular Weight	628.64 g/mol
Synonyms	Thalidomide-PEG4-N3; (S)-Thalidomide-4-amino-PEG4-azide; 2-(2,6-Dioxopiperidin-3-yl)-4-amido-isoindoline-1,3-dione-PEG4-azide; N-(Azido-PEG4)-N'-(thalidomide-4-oxy)succinamide; CRBN Ligand-Linker Conjugate 4; E3 Ligase Ligand-Linker Conjugate; PROTAC Linker; Azido-PEG4-thalidomide
EINECS	Contact for details

Quality Control

Our Thalidomide-o-Amido-Peg4-Azide is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment, NMR and mass spectrometry for structural confirmation. Certificates of Analysis (COA) detailing all specifications and test results are provided to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, moisture-free environment. The compound is hygroscopic and light-sensitive; allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.