Description

(2-(((tert-Butyldimethylsilyl)Oxy)Methyl)Pyridin-4-Yl)Boronic Acid is a sophisticated organoboron building block featuring a pyridine core protected by a tert-butyldimethylsilyl (TBDMS) ether group. This compound matters for its dual functionality, serving as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block in Suzuki-Miyaura cross-coupling reactions for the synthesis of novel drug candidates, especially those containing bipyridine or related heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its boronic acid functionality for creating diverse chemical libraries.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the creation of organic electronic materials and polymers where the pyridine moiety and boronic acid group impart specific electronic or self-assembly properties.
• Chemical Biology Probes: Utilized in the development of molecular probes and sensors due to the reactivity of the boronic acid group with diols and other biological targets.
• Process Chemistry: Valued in scaling up synthetic routes where the TBDMS protecting group provides stability during multi-step synthesis.

Basic Information

Item	Detail
Product Name	(2-(((tert-Butyldimethylsilyl)Oxy)Methyl)Pyridin-4-Yl)Boronic Acid
CAS No.	2377609-30-6
Molecular Formula	C12H22BNO3Si
Molecular Weight	267.21 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(((tert-butyldimethylsilyl)oxy)methyl)pyridine; 2-(((tert-Butyldimethylsilyl)oxy)methyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; (2-(((Tert-Butyldimethylsilyl)Oxy)Methyl)Pyridin-4-Yl)Boronic Acid, pinacol ester; TBDMS-protected pyridinylboronic acid; 4-Borono-2-(((tert-butyldimethylsilyl)oxy)methyl)pyridine
EINECS	Contact for details

Quality Control

Our (2-(((tert-Butyldimethylsilyl)Oxy)Methyl)Pyridin-4-Yl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and easily oxidized nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.