Description

Methyl 2-Bromo-4-Fluoro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate CAS NO 2377607-39-9 is a high-purity, multifunctional boronic ester derivative designed for advanced synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for drug discovery and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, leveraging the fluorine and bromine substituents for enhanced biological activity and environmental stability.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where the boronate ester functionality enables precise molecular engineering.
• Ligand and Catalyst Development: Serves as a versatile scaffold for constructing complex ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized to synthesize tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized fine chemicals.

Basic Information

Product Name	Methyl 2-Bromo-4-Fluoro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate
CAS No.	2377607-39-9
Molecular Formula	C14H17BBrFO4
Molecular Weight	359.00 g/mol
Synonyms	2-Bromo-4-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester; Methyl 2-bromo-4-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 2-Bromo-4-fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)methyl benzoate; Benzoic acid, 2-bromo-4-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; Pinacol (2-bromo-4-fluoro-5-methoxycarbonylphenyl)boronate; 2-Bromo-4-fluoro-5-methoxycarbonylphenylboronic acid pinacol ester; 2377607-39-9
EINECS	Contact for details

Quality Control

Every batch of Methyl 2-Bromo-4-Fluoro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.