Description

Spiro[2H-Indene-2,4'-Piperidine]-1'-Carboxylic Acid, 5-Bromo-3-[[(R)-(1,1-Dimethylethyl)Sulfinyl]Amino]-1,3-Dihydro-, 1,1-Dimethylethyl Ester, (3S)- is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and chiral sulfinamide structure. This compound is critical for research and development in medicinal chemistry, particularly for the synthesis of novel drug candidates targeting central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers requiring precise stereochemical control and reliable quality for complex synthetic pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization studies to explore structure-activity relationships (SAR) due to its unique spirocyclic scaffold.
• Process Chemistry Development: Serves as a critical intermediate in scaling up synthetic routes for preclinical and clinical trial material production.
• Chiral Synthesis: The (R)-tert-butylsulfinyl group acts as a versatile chiral auxiliary for asymmetric synthesis, enabling the creation of enantiomerically pure compounds.
• Library Synthesis: Valuable for generating focused chemical libraries for high-throughput screening (HTS) in drug discovery programs.

Basic Information

Product Name	Spiro[2H-Indene-2,4'-Piperidine]-1'-Carboxylic Acid, 5-Bromo-3-[[(R)-(1,1-Dimethylethyl)Sulfinyl]Amino]-1,3-Dihydro-, 1,1-Dimethylethyl Ester, (3S)-
CAS No.	2377355-25-2
Molecular Formula	C22H31BrN2O3S
Molecular Weight	483.46 g/mol
Synonyms	(3S)-5-Bromo-3-[[(R)-(1,1-Dimethylethyl)sulfinyl]amino]-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl (3S)-5-bromo-3-[[(R)-tert-butylsulfinyl]amino]-2,3-dihydro-1H-spiro[indene-2,4'-piperidine]-1'-carboxylate; 5-Bromo-3-[[(R)-tert-butylsulfinyl]amino]-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylic acid tert-butyl ester (3S)-; Spiro[indene-2,4'-piperidine] intermediate 2377355-25-2; (3S)-5-Bromo-N-[(R)-tert-butylsulfinyl]-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxamide tert-butyl ester; Advanced sulfinamide spirocyclic intermediate
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality management systems to ensure batch-to-batch consistency and purity suitable for pharmaceutical research. Quality is verified through a comprehensive suite of analytical techniques including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each batch, documenting identity, purity, and impurity profiles. Our production adheres to cGMP guidelines where applicable to support our clients' regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.