Description

Dbco-Peg2-Nh-Boc CAS NO 2377004-08-3 is a heterobifunctional polyethylene glycol (PEG) linker featuring a dibenzocyclooctyne (DBCO) group for strain-promoted azide-alkyne cycloaddition (SPAAC) and a Boc-protected amine for subsequent deprotection and conjugation. This compound is essential for creating stable, bioorthogonal linkages in complex bioconjugation workflows without the need for cytotoxic copper catalysts. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceutical development, proteomics, and advanced materials science for labeling, crosslinking, and constructing antibody-drug conjugates (ADCs) and other targeted therapeutics.

Application

• Bioconjugation and ADC Development: Enables site-specific, copper-free click chemistry conjugation of payloads (e.g., drugs, toxins, fluorophores) to antibodies, proteins, or peptides.
• Proteomics and Biomarker Research: Used for labeling and enriching azide-tagged biomolecules for mass spectrometry analysis and cellular imaging.
• Polymer and Materials Science: Serves as a functional building block for synthesizing smart hydrogels, surface coatings, and drug delivery nanoparticles with tailored bio-interfaces.
• Diagnostic Reagent Formulation: Facilitates the development of sensitive immunoassays and diagnostic probes through stable linker technology.
• Chemical Biology Tool Development: A key reagent for creating activity-based probes and studying protein-protein interactions in live cells.
• Precision Medicine Platforms: Integral to constructing next-generation theranostic agents that combine targeting, imaging, and therapeutic functions.

Basic Information

Product Name	Dbco-Peg2-Nh-Boc
CAS No.	2377004-08-3
Molecular Formula	C31H38N2O7
Molecular Weight	550.65 g/mol
Synonyms	DBCO-PEG2-amine-Boc; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2-{2-[(tert-butoxycarbonyl)amino]ethoxy}ethoxy)acetate; DBCO-PEG2-Boc-amine; Boc-NH-PEG2-DBCO; Azadibenzocyclooctyne-PEG2-amine-Boc; DBCO-PEG2-NH-Boc; tert-Butyl (2-{2-[2-({(1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl}methoxy)-2-oxoethoxy]ethoxy}ethyl)carbamate
EINECS	Contact for details

Quality Control

Our Dbco-Peg2-Nh-Boc is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.