Description

tert-Butyl (6S)-6-Hydroxy-2-Azaspiro[3.4]Octane-2-Carboxylate is a high-purity, chiral spirocyclic building block of significant interest in modern pharmaceutical research and development. This compound serves as a critical intermediate for constructing complex molecular architectures, enabling the synthesis of novel therapeutic agents with enhanced biological activity and selectivity. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the discovery and scalable production of new drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its constrained spirocyclic scaffold.
• Process Chemistry: Serves as a building block in the development of efficient, scalable commercial routes for candidate drugs.
• Proteolysis Targeting Chimera (PROTAC) Development: Employed in the construction of linkers and warheads for targeted protein degradation therapeutics.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective synthesis to introduce the desired (S)-configuration.
• Chemical Biology: Acts as a molecular probe for studying enzyme function and protein-ligand interactions.

Basic Information

Product Name	tert-Butyl (6S)-6-Hydroxy-2-Azaspiro[3.4]Octane-2-Carboxylate
CAS No.	2376903-72-7
Molecular Formula	C12H21NO3
Molecular Weight	227.30 g/mol
Synonyms	(6S)-6-Hydroxy-2-azaspiro[3.4]octane-2-carboxylic acid tert-butyl ester; tert-Butyl (6S)-6-hydroxy-2-azaspiro[3.4]octane-2-carboxylate; 2-Azaspiro[3.4]octane-2-carboxylic acid, 6-hydroxy-, 1,1-dimethylethyl ester, (6S)-; (S)-tert-Butyl 6-hydroxy-2-azaspiro[3.4]octane-2-carboxylate; (S)-6-Hydroxy-2-azaspiro[3.4]octane-2-carboxylic acid tert-butyl ester; Boc-Protected (S)-6-Hydroxy-2-azaspiro[3.4]octane
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl (6S)-6-Hydroxy-2-Azaspiro[3.4]Octane-2-Carboxylate is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for use in GMP and non-GMP development applications. Certificates of Analysis (COA) detailing purity (typically by HPLC/NMR), chiral purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.