Description

Azido-PEG8-t-Boc-hydrazide is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal azide group and a Boc-protected hydrazide. This compound is engineered to facilitate the controlled conjugation of biomolecules and other functional entities via click chemistry and hydrazone bond formation. It is a critical reagent for researchers and developers in the pharmaceutical and biotechnology sectors, particularly for creating antibody-drug conjugates (ADCs), peptide modifications, and advanced polymer therapeutics.

Application

• Bioconjugation and ADC Development: The azide group enables efficient, site-specific conjugation via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC), while the protected hydrazide allows for subsequent carbonyl coupling, ideal for constructing complex drug-linker systems.
• PEGylation Reagent: Serves as a versatile PEG spacer to improve the solubility, stability, and pharmacokinetic profiles of therapeutic peptides, proteins, and small molecule drugs.
• Crosslinking Agent: Used in material science and hydrogel formation to crosslink polymers or functionalize surfaces with bioactive molecules.
• Proteomics Research: Acts as a tool for chemical proteomics, enabling the labeling and enrichment of target biomolecules for identification and study.
• Diagnostic Reagent Synthesis: Employed in the development of contrast agents and diagnostic probes where controlled linkage and water solubility are paramount.
• Polymer Chemistry: A valuable building block for synthesizing functionalized, biocompatible polymers with tailored reactive handles for further modification.

Basic Information

Product Name	Azido-PEG8-t-Boc-hydrazide
CAS No.	2353410-12-3
Molecular Formula	C26H51N5O12
Molecular Weight	625.71 g/mol
Synonyms	Azido-PEG8-Boc-hydrazide; N-(t-Butoxycarbonyl)-N'-[2-[2-[2-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]hydrazine; Boc-NH-NH-PEG8-N3; α-Azido-ω-Boc-hydrazide octaethylene glycol; 1-Boc-1H-pyrazole-4-carboxylic acid PEG8 azide derivative (related); Azido-PEG8-t-butyl carbazate; PEG8 Azide Boc Hydrazide; 2,5,8,11,14,17,20,23-Octaoxapentacosan-25-azido, 1-(1,1-dimethylethyl) 2-hydrozinedicarboxylate
EINECS	Contact for details

Quality Control

Every batch of Azido-PEG8-t-Boc-hydrazide is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard quality commitment includes HPLC purity ≥95% and verification of functional group integrity. A detailed Certificate of Analysis (COA) providing specifications for assay, identity (NMR/IR), and related substances is supplied with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation and an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Azide)	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.