Description

Tco-Peg8-Tfp Ester CAS NO 2353410-06-5 is a specialized heterobifunctional polyethylene glycol (PEG) linker featuring a 1,2,4,5-tetrazine (Tz) reactive group and a trans-cyclooctene (TCO) moiety, designed for rapid, bioorthogonal conjugation in aqueous environments. This compound is critical for enabling high-efficiency, catalyst-free click chemistry applications, particularly in time-sensitive biological systems. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, radiopharmaceutical development, and advanced materials science for labeling, drug delivery, and diagnostic probe construction.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Site-specific labeling of proteins, antibodies, and peptides via rapid inverse electron-demand Diels-Alder (IEDDA) click chemistry.
• Pretargeted Radioimmunotherapy and Imaging: Facilitating multi-step pretargeting strategies for delivering radionuclides (e.g., 177Lu, 225Ac) to cancer cells with improved tumor-to-background ratios.
• Fluorescent and Diagnostic Probe Synthesis: Conjugation of tetrazine-modified dyes, quenchers, or contrast agents to TCO-labeled targeting molecules for in vitro and in vivo imaging.
• Surface Functionalization and Biomaterial Engineering: Modifying nanoparticles, hydrogels, and other material surfaces with bioactive ligands for controlled cell interaction and drug release.
• Chemical Biology and Proteomics: As a tool compound for studying dynamic cellular processes, protein trafficking, and enzyme activity through time-resolved labeling.
• Oligonucleotide and Nucleic Acid Modification: Creating functionalized oligonucleotides for targeted delivery, sensing, and therapeutic applications.

Basic Information

Product Name	Tco-Peg8-Tfp Ester
CAS No.	2353410-06-5
Molecular Formula	C52H78N6O15
Molecular Weight	1027.2 g/mol
Synonyms	trans-Cyclooctene-PEG8-Tetrazine-PFP Ester; TCO-PEG8-Tetrazine-PFP Ester; (E)-Cyclooct-4-enyl 3,6,9,12,15,18,21,24-octaoxahexacosan-26-yl (perfluorophenyl) 6-(1,2,4,5-tetrazin-3-yl)-2,5,8,11-tetraoxatridecan-13-oate; TCO-PEG8-Tz-PFP; TCO-(PEG)8-Tetrazine Pentafluorophenyl Ester; Heterobifunctional PEG Linker TCO-PEG8-Tz-PFP; Tetrazine-PEG8-TCO Active Ester
EINECS	Contact for details

Quality Control

Our Tco-Peg8-Tfp Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and Mass Spectrometry, to ensure it meets the high standards required for sensitive research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize condensation and hydrolysis.

Specification

Item	Specification
Appearance	Yellow to orange viscous oil or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.