Description

Methyltetrazine-Peg5-Triethoxysilane CAS NO 2353410-01-0 is a heterobifunctional crosslinking agent that combines the bioorthogonal reactivity of a methyltetrazine group with the surface-anchoring capability of a triethoxysilane, connected by a hydrophilic poly(ethylene glycol) spacer. This compound is engineered for creating stable, functionalized surfaces in aqueous and biological environments, enabling advanced material science and bioconjugation applications. It is essential for researchers and manufacturers in biotech, pharmaceuticals, and advanced materials who require precise and robust surface modification for diagnostics, drug delivery systems, and sensor development.

Application

• Surface Functionalization for Biosensors: Immobilization of biomolecules (antibodies, enzymes, DNA) onto silicon, glass, or metal oxide substrates to create highly sensitive diagnostic and detection platforms.
• Bioorthogonal Labeling & Conjugation: Site-specific modification of proteins, antibodies, or nanoparticles via the rapid and selective inverse electron-demand Diels-Alder (IEDDA) reaction of the methyltetrazine group.
• Hydrogel and Biomaterial Fabrication: Crosslinking agent for synthesizing PEG-based hydrogels with tailored mechanical properties and biofunctionalization sites for tissue engineering and 3D cell culture.
• Chromatography Media Derivatization: Modification of silica-based stationary phases for affinity or ion-exchange chromatography used in protein purification and analysis.
• Microarray and Chip Technology: Creating patterned surfaces with specific chemical functionalities for high-throughput screening and genomic/proteomic studies.
• Targeted Drug Delivery Systems: Conjugation of therapeutic payloads to targeting ligands or surface modification of drug carriers like liposomes and polymeric nanoparticles.

Basic Information

Product Name	Methyltetrazine-Peg5-Triethoxysilane
CAS No.	2353410-01-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	3-(Methyl)-1,2,4,5-tetrazine-PEG5-triethoxysilane; Methyltetrazine-PEG5-silane; MeTz-PEG5-Si(OEt)3; Silane-PEG5-Methyltetrazine; Triethoxy(2,5,8,11,14-pentaoxa-17-azaheptadec-16-yl)silane derivative; Tetrazine-PEG-silane crosslinker; Bioorthogonal silane linker
EINECS	Contact for details

Quality Control

Every batch of Methyltetrazine-Peg5-Triethoxysilane is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and functional integrity. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with each shipment to guarantee reproducible performance for your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.