Description

Dbco-Peg12-Acid CAS NO 2353410-00-9 is a heterobifunctional polyethylene glycol (PEG) linker featuring a dibenzocyclooctyne (DBCO) group for strain-promoted azide-alkyne cycloaddition (SPAAC) and a terminal carboxylic acid for further conjugation via amide bond formation. This compound is essential for creating stable, well-defined bioconjugates without the need for cytotoxic copper catalysts, enabling efficient and bioorthogonal labeling. It is primarily needed by researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced materials science for applications such as antibody-drug conjugate (ADC) construction, peptide modification, and surface functionalization.

Application

• Bioconjugation and ADC Development: Used as a key linker for site-specific conjugation of cytotoxic drugs to antibodies or proteins via its DBCO and carboxylic acid functionalities.
• Peptide and Protein Modification: Enables the PEGylation of peptides or proteins to improve solubility, stability, and pharmacokinetic properties.
• Surface Functionalization: Facilitates the bioorthogonal immobilization of biomolecules onto nanoparticles, biosensors, or other material surfaces.
• Click Chemistry Reagent: Serves as a critical reagent for copper-free click chemistry reactions in live-cell labeling and in vivo imaging studies.
• Polymer and Dendrimer Synthesis: Acts as a building block for synthesizing complex, multi-functional polymeric architectures.
• Diagnostic Probe Construction: Utilized in the development of fluorescent or radioactive diagnostic probes for targeted imaging.
• Hydrogel and Biomaterial Fabrication: Incorporated into cross-linked networks to create functional, biocompatible hydrogels for tissue engineering and drug delivery.
• Liposome and Micelle Modification: Used to attach targeting ligands or stealth PEG layers to lipid-based drug delivery systems.

Basic Information

Product Name	Dbco-Peg12-Acid
CAS No.	2353410-00-9
Molecular Formula	C58H91NO26
Molecular Weight	~1186.3 g/mol
Synonyms	DBCO-PEG12-COOH; DBCO-PEG12-Acid; Dibenzocyclooctyne-PEG12-Acid; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (1-{2-[2-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-carboxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl) carbamate; DBCO-PEG12-Acetic Acid; Azadibenzocyclooctyne-PEG12-Acid; DBCO-PEG12-Propionic Acid (common naming); DBCO-PEG12-NHS Ester precursor
EINECS	Contact for details

Quality Control

Our Dbco-Peg12-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical research and development applications. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, and common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.