Description

n-(Boc-Peg2)-n-Bis(Peg3-Azide) is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a Boc-protected amine and two terminal azide groups, enabling orthogonal conjugation strategies. This compound is engineered for the precise construction of complex biomolecular architectures, such as antibody-drug conjugates (ADCs) and peptide-PEG conjugates, through click chemistry and amine coupling reactions. It is a critical reagent for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced materials science who require high-purity, functionalized linkers.

Application

• Bioconjugation and ADC (Antibody-Drug Conjugate) Development: Serves as a key linker for site-specific conjugation of cytotoxic drugs to antibodies via its orthogonal reactive groups.
• Peptide and Protein Modification: Used to introduce PEG chains (PEGylation) to enhance solubility, stability, and pharmacokinetic properties of therapeutic peptides and proteins.
• Click Chemistry Scaffolds: The dual azide terminals are ideal for copper-catalyzed azide-alkyne cycloaddition (CuAAC) to create dendrimers, polymers, or surface modifications.
• Materials Science and Hydrogel Formation: Acts as a crosslinking agent for creating functionalized hydrogels and polymeric networks with tailored properties.
• Diagnostic Reagent Synthesis: Utilized in the development of fluorescent probes, imaging agents, and diagnostic assay components.
• Drug Delivery System Design: Facilitates the construction of sophisticated drug delivery vehicles like micelles and nanoparticles with controlled release profiles.

Basic Information

Product Name	n-(Boc-Peg2)-n-Bis(Peg3-Azide)
CAS No.	2353409-46-6
Molecular Formula	C31H59N7O12
Molecular Weight	721.85 g/mol
Synonyms	1-tert-Butyl 14,14'-(2,2'-(2-(2-(2-Azidoethoxy)ethoxy)ethyl)azanediyl)bis(ethane-2,1-diyl) bis(4,7,10-trioxa-13-azapentadecanoate); Boc-NH-PEG2-N(PEG3-N3)2; tert-Butyl (1-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-1,1-bis(2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)ethylcarbamate; Boc-Amine-PEG2-Bis(PEG3-Azide); Heterobifunctional PEG Crosslinker, Boc-Amine and Azide; Azido-PEG3-N-Boc-PEG2-Azido; N-Boc-1,1-bis[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]-1,2-ethanediamine derivative
EINECS	Contact for details

Quality Control

Our n-(Boc-Peg2)-n-Bis(Peg3-Azide) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with research and pharmaceutical-grade standards. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature in a dry environment before opening to prevent moisture condensation. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.