Description

Fmoc-2-Amino-5-Phenyl(2,3-Difluoro)-L-Pentanoic Acid is a sophisticated, non-natural amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters because it provides a key, fluorinated building block for introducing specific structural and electronic modifications into peptide sequences, enabling the development of novel bioactive molecules with enhanced stability and targeted properties. It is essential for research and development chemists in the pharmaceutical and biotechnology sectors who are focused on creating next-generation peptide therapeutics, diagnostics, and chemical probes.

Application

• As a critical building block in the solid-phase synthesis of fluorinated peptide analogs for pharmaceutical research.
• For the incorporation of difluorophenylalanine motifs into peptide backbones to modulate conformation, metabolic stability, and lipophilicity.
• In the development of peptide-based drug candidates targeting GPCRs, enzymes, and protein-protein interactions.
• Use in the synthesis of custom peptides for structure-activity relationship (SAR) studies and medicinal chemistry optimization.
• As a specialized reagent for chemical biology tools, including fluorescent probes, affinity tags, and enzyme substrates.
• For the preparation of peptide libraries used in high-throughput screening for drug discovery.

Basic Information

Product Name	Fmoc-2-Amino-5-Phenyl(2,3-Difluoro)-L-Pentanoic Acid
CAS No.	2349313-65-9
Molecular Formula	C26H23F2NO4
Molecular Weight	451.46 g/mol
Synonyms	Fmoc-2,3-difluoro-DL-phenylalanine; Fmoc-(2,3-F2)Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,3-difluoro-L-phenylalanine; Fmoc-2,3-difluoro-L-phenylalanine; 2,3-Difluoro-N-Fmoc-L-phenylalanine; N-Fmoc-2,3-difluoro-L-phenylalanine; Fmoc-L-2,3-difluorophenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(2,3-difluorophenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for peptide synthesis. Every batch is characterized by HPLC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) are available upon request, detailing specific analytical results. We adhere to a quality management system to guarantee batch-to-batch consistency and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.