Description

2-[2-[(tert-Butyldimethylsilyl)Oxy]Phenyl]Acetonitrile is a high-value, protected synthetic intermediate crucial for advanced organic synthesis. This compound is specifically engineered to provide a stable, silyl-protected phenolic precursor, enabling complex multi-step reactions in sensitive chemical environments. It is primarily sought after by research and development laboratories and production facilities in the pharmaceutical and fine chemical sectors for the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Fine Chemical Synthesis: Used in the preparation of specialty chemicals, agrochemicals, and advanced materials requiring protected functional groups.
• Organic Research & Development: Serves as a critical reagent in academic and industrial R&D for exploring new synthetic pathways and methodologies.
• Peptide Mimetics & Bioconjugation: Utilized in the construction of peptide analogs and for introducing nitrile-functionalized linkers in bioconjugation chemistry.
• Ligand and Catalyst Development: Acts as a precursor for creating novel ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	2-[2-[(tert-Butyldimethylsilyl)Oxy]Phenyl]Acetonitrile
CAS No.	2338684-84-5
Molecular Formula	C14H21NOSi
Molecular Weight	247.41 g/mol
Synonyms	2-(2-((tert-Butyldimethylsilyl)oxy)phenyl)acetonitrile; [2-[(tert-Butyldimethylsilyl)oxy]phenyl]acetonitrile; 2-(2-(Tert-butyldimethylsilyloxy)phenyl)acetonitrile; 2-(2-Hydroxyphenyl)acetonitrile TBDMS ether; o-(Cyanomethyl)phenol TBDMS ether; TBDMS-protected o-cyanomethylphenol; 2-(2-((tert-Butyldimethylsilyl)oxy)phenyl)ethanenitrile
EINECS	Contact for details

Quality Control

Our 2-[2-[(tert-Butyldimethylsilyl)Oxy]Phenyl]Acetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in cGMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccator for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.