Description

Mavorixafor Trihydrochloride is a potent and selective small-molecule antagonist of the CXCR4 chemokine receptor. This compound is of significant interest for its role in modulating the CXCR4/CXCL12 axis, a key pathway involved in cell migration, proliferation, and survival. It is primarily utilized by pharmaceutical researchers and manufacturers in the development of novel therapeutics for oncology, immunology, and genetic disorders such as WHIM syndrome.

Application

• Pharmaceutical Research & Development (R&D): Serves as a critical reference standard and active pharmaceutical ingredient (API) in preclinical and clinical studies targeting CXCR4.
• Oncology Therapeutics: Investigated for its potential to inhibit cancer metastasis and sensitize tumors to chemotherapy by blocking CXCR4-mediated signaling pathways.
• Immunology and Stem Cell Mobilization: Used in studies related to stem cell transplantation for its ability to mobilize hematopoietic stem cells from the bone marrow into the bloodstream.
• WHIM Syndrome Treatment: A key component in developing treatments for this rare genetic immunodeficiency disorder caused by gain-of-function mutations in the CXCR4 gene.
• Biochemical Assay Development: Employed as a high-purity ligand in cell-based assays, receptor binding studies, and high-throughput screening (HTS) platforms.
• Process Chemistry & Scale-Up: Supplied for process optimization, formulation development, and the production of drug product batches under cGMP conditions.

Basic Information

Product Name	Mavorixafor Trihydrochloride
CAS No.	2309699-17-8
Molecular Formula	C₂₆H₃₄Cl₃N₇O₃
Molecular Weight	599.95 g/mol
Synonyms	Mavorixafor HCl; X4P-001; AMD 070 trihydrochloride; CXCR4 antagonist X4P-001; 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane] trihydrochloride; (1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane]) trihydrochloride; AMD0700 trihydrochloride
EINECS	Contact for details

Quality Control

Our Mavorixafor Trihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis (GC), and identity confirmation (IR, MS), to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) with detailed chromatograms and full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0% (anhydrous basis)
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤20 ppm
Single Unknown Impurity	≤0.5%
Total Impurities	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.