Description

Citrulline-Specific Probe-Rhodamine is a high-purity, fluorescent chemical probe designed for the selective detection and imaging of citrulline residues in proteins. This compound matters for researchers and developers in life sciences as it enables critical studies into protein citrullination, a key post-translational modification linked to autoimmune diseases like rheumatoid arthritis. Professionals in pharmaceutical R&D, diagnostic assay development, and academic biochemistry laboratories need this specific probe to advance their work in biomarker discovery and therapeutic target validation.

Application

• Biomarker Research & Detection: Selective fluorescent labeling of citrullinated proteins in complex biological samples for disease biomarker studies.
• Autoimmune Disease Mechanism Studies: Investigation of protein citrullination pathways in conditions such as rheumatoid arthritis, multiple sclerosis, and lupus.
• In Vitro Diagnostic (IVD) Assay Development: Serving as a key component in the development of fluorescent immunoassays and ELISA kits for detecting anti-citrullinated protein antibodies (ACPAs).
• Pharmaceutical Screening: High-throughput screening (HTS) applications to identify and characterize peptidylarginine deiminase (PAD) enzyme inhibitors.
• Cellular & Tissue Imaging: Fluorescence microscopy and histochemistry for the spatial visualization of citrullination events within cells and tissue sections.
• Bioconjugation & Probe Design: Acting as a versatile scaffold for creating advanced multimodal probes by conjugating with other detection moieties.

Basic Information

Product Name	Citrulline-Specific Probe-Rhodamine
CAS No.	2309313-01-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Citrulline Probe-Rhodamine; Rhodamine-conjugated Citrulline Probe; Citrulline Detection Probe; Fluorescent Citrulline Sensor; Anti-citrulline Rhodamine Tag; Citrulline-Rhodamine Conjugate; Protein Citrullination Imaging Agent
EINECS	Contact for details

Quality Control

Our Citrulline-Specific Probe-Rhodamine is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for sensitive research applications. Certificates of Analysis (COA) with detailed chromatographic and spectral data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a dry atmosphere before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Red to purple solid or lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with expected molecular mass
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers
Fluorescence Properties	Excitation/Emission maxima typical for Rhodamine derivatives
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.