Description

2-Methyl-2-azaspiro[3.3]heptan-6-amine dihydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic amine structure. This compound is of significant commercial interest for its role as a critical building block in modern medicinal chemistry, particularly in the development of novel therapeutic agents. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of new chemical entities (NCEs) for drug discovery programs targeting central nervous system (CNS) and other therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of active pharmaceutical ingredients (APIs) and preclinical drug candidates.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop novel small molecule therapeutics.
• CNS Drug Discovery: Its structural motif is valuable for creating compounds targeting neurological receptors and enzymes.
• Chemical Biology Probes: Utilized in the development of tool compounds and molecular probes for biological pathway investigation.
• Custom Synthesis: A foundational starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) campaigns.

Basic Information

Product Name	2-Methyl-2-azaspiro[3.3]heptan-6-amine dihydrochloride
CAS No.	2306276-66-2
Molecular Formula	C7H16N2 · 2HCl
Molecular Weight	209.14 g/mol (Free base: 128.22 g/mol)
Synonyms	6-Amino-2-methyl-2-azaspiro[3.3]heptane dihydrochloride; 2-Methyl-2-azaspiro[3.3]heptan-6-amine hydrochloride (1:2); 2-Methyl-2-azaspiro[3.3]heptan-6-amine, dihydrochloride; 2-Methyl-2-azaspiro[3.3]heptan-6-amine HCl; 2-Methyl-2-azaspiro[3.3]heptan-6-amine, 2HCl; Spiro[3.3]heptan-6-amine, 2-methyl-2-aza-, dihydrochloride; 2306276-66-2
EINECS	Contact for details

Quality Control

Our 2-Methyl-2-azaspiro[3.3]heptan-6-amine dihydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. All materials undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.