Description

Spiro[3H-Indole-3,4′-Piperidin]-2(1H)-One, 5-Methyl-, Hydrochloride (1:1) is a high-purity pharmaceutical intermediate and research chemical of significant interest in modern drug discovery. This compound is valued for its complex spirocyclic indole-piperidine scaffold, which is a privileged structure in medicinal chemistry for targeting central nervous system and other therapeutic areas. It is primarily sought by research institutions and pharmaceutical companies engaged in the synthesis and development of novel bioactive molecules and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, particularly those targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for hit-to-lead optimization in drug discovery programs.
• Biochemical Tool Compound: Serves as a reference standard or a probe in pharmacological assays to study specific biological pathways and protein interactions.
• API Development: Employed in the research and development stages of new Active Pharmaceutical Ingredients (APIs) that utilize the spirocyclic indole core.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.

Basic Information

Product Name	Spiro[3H-Indole-3,4′-Piperidin]-2(1H)-One, 5-Methyl-, Hydrochloride (1:1)
CAS No.	2306270-99-3
Molecular Formula	C14H17ClN2O
Molecular Weight	264.75 g/mol
Synonyms	5-Methylspiro[indoline-3,4'-piperidin]-2-one hydrochloride; 5-Methyl-1'H-spiro[indoline-3,4'-piperidine]-2-one hydrochloride; 5-Methyl-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine] hydrochloride; Spiro[3H-indole-3,4'-piperidine]-2(1H)-one, 5-methyl-, hydrochloride; 2306270-99-3; 5-Methyl-spiro[indoline-3,4'-piperidine]-2-one HCl
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized and controlled using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing all relevant specifications are available upon request. We adhere to a quality management system suitable for supplying materials for research and development under cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under anhydrous conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.