Description

4-Azaspiro[2.5]Octane-4-Carboxylic Acid, 7-Hydroxy-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and azetidine scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system (CNS) and other therapeutic areas. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those with spirocyclic and constrained ring systems.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve pharmacokinetic properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential component for constructing linkers or warheads due to its rigid, three-dimensional structure.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Academic Research: Used in universities and research institutes for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Item	Details
Product Name	4-Azaspiro[2.5]Octane-4-Carboxylic Acid, 7-Hydroxy-, 1,1-Dimethylethyl Ester
CAS No.	2306269-68-9
Molecular Formula	C12H21NO3
Molecular Weight	227.30 g/mol
Synonyms	tert-Butyl 7-hydroxy-4-azaspiro[2.5]octane-4-carboxylate; 4-Boc-7-hydroxy-4-azaspiro[2.5]octane; 7-Hydroxy-4-azaspiro[2.5]octane-4-carboxylic acid tert-butyl ester; 4-Azaspiro[2.5]octane-4-carboxylic acid, 7-hydroxy-, 1,1-dimethylethyl ester; 4-(tert-Butoxycarbonyl)-7-hydroxy-4-azaspiro[2.5]octane; Boc-4-aza-7-hydroxyspiro[2.5]octane
EINECS	Contact for details

Quality Control

Our 4-Azaspiro[2.5]Octane-4-Carboxylic Acid, 7-Hydroxy-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is sensitive to strong acids and organic solvents; keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.