Description

2-Azaspiro[3.4]Octane-2,5-Dicarboxylic Acid, 2-(1,1-Dimethylethyl) Ester is a high-value, spirocyclic building block and protected amino acid derivative essential for advanced organic synthesis. Its rigid, three-dimensional structure is critical for modulating the physicochemical properties and biological activity of target molecules in pharmaceutical research. This compound is primarily sought after by medicinal chemists and process development scientists working in drug discovery and development, particularly for creating novel small molecule therapeutics targeting central nervous system (CNS) disorders and other complex diseases.

Application

• Pharmaceutical Intermediate: A key chiral scaffold in the synthesis of novel active pharmaceutical ingredients (APIs), especially for CNS-targeting drugs.
• Proteolysis Targeting Chimera (PROTAC) Development: Used as a component in linker design or as part of the warhead due to its spirocyclic rigidity and functional handles.
• Peptidomimetic Chemistry: Serves as a constrained, non-natural amino acid analog to enhance metabolic stability and binding affinity in peptide-based drug candidates.
• Chemical Biology Probes: Employed in the construction of molecular probes for studying enzyme function and protein-protein interactions.
• Agrochemical Research: Utilized as a sophisticated intermediate in the development of new generation herbicides and fungicides with novel modes of action.
• Material Science: Acts as a monomer or cross-linker precursor for specialty polymers with unique thermal and mechanical properties.

Basic Information

Product Name	2-Azaspiro[3.4]Octane-2,5-Dicarboxylic Acid, 2-(1,1-Dimethylethyl) Ester
CAS No.	2306265-72-3
Molecular Formula	C14H23NO4
Molecular Weight	269.34 g/mol
Synonyms	tert-Butyl 2,5-dioxo-2-azaspiro[3.4]octane-2-carboxylate; 2-(tert-Butoxycarbonyl)-2-azaspiro[3.4]octane-2,5-dione; 2-Azaspiro[3.4]octane-2,5-dione, 2-(1,1-dimethylethyl) ester; Boc-Protected 2-Azaspiro[3.4]octane-2,5-dione; 2-Boc-2-azaspiro[3.4]octane-2,5-dione; Spirocyclic Glutamate Derivative; 2306265-72-3
EINECS	Contact for details

Quality Control

Every batch of 2-Azaspiro[3.4]Octane-2,5-Dicarboxylic Acid, 2-(1,1-Dimethylethyl) Ester is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the identity, purity, and consistency required for critical R&D and scale-up activities. A detailed Certificate of Analysis (COA) including results from HPLC, NMR, and MS is supplied with each shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.