Description

6-Thia-2-Azaspiro[3.4]Octane, 6,6-Dioxide, Hydrochloride (1:1) is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic sulfonamide scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, especially within central nervous system (CNS) and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting protease enzymes or G-protein-coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for lead optimization due to its constrained, three-dimensional spirocyclic structure.
• Chemical Biology Probes: Serves as a core scaffold for developing tool compounds and probes to study biological pathways and target engagement.
• Pre-clinical Drug Development: Employed in the synthesis of compounds for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.

Basic Information

Product Name	6-Thia-2-Azaspiro[3.4]Octane, 6,6-Dioxide, Hydrochloride (1:1)
CAS No.	2306261-59-4
Molecular Formula	C7H12ClNO3S
Molecular Weight	225.69 g/mol
Synonyms	6-Thia-2-azaspiro[3.4]octane 6,6-dioxide hydrochloride; 2-Azaspiro[3.4]octane-6-thia-6,6-dioxide hydrochloride; 1-Azaspiro[3.4]octane-7-thia-7,7-dioxide hydrochloride (tautomer); Spiro[cyclopropane-1,2'-thiazolidine] 1',1'-dioxide hydrochloride; 6-Thia-2-azaspiro[3.4]octane-6,6-dioxide HCl; 2306261-59-4; (1R,5S)-6-Thia-2-azaspiro[3.4]octane 6,6-dioxide hydrochloride (if stereospecific)
EINECS	Contact for details

Quality Control

Our 6-Thia-2-Azaspiro[3.4]Octane, 6,6-Dioxide, Hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for water content. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under dry, inert conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.