Description

1,2,4-Pyrrolidinetricarboxylic Acid, 1-(1,1-Dimethylethyl) 2-Methyl Ester, (2S,4R)- is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its value lies in its multifunctional pyrrolidine core, which serves as a versatile scaffold for constructing complex molecules with precise three-dimensional architecture. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, asymmetric synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic disorders.
• Asymmetric Catalysis Ligand Precursor: Used in the synthesis of sophisticated chiral ligands and organocatalysts for enantioselective transformations.
• Peptidomimetic & Constrained Peptide Design: The pyrrolidine structure is integral for creating conformationally restricted peptide analogs and peptidomimetics in drug discovery.
• Agrochemical Synthesis: Serves as a building block for developing novel, stereospecific herbicides, fungicides, and plant growth regulators.
• Material Science Research: Investigated as a monomer or cross-linking agent for creating novel polymers with specific chiral or functional properties.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development in synthetic organic chemistry.

Basic Information

Product Name	1,2,4-Pyrrolidinetricarboxylic Acid, 1-(1,1-Dimethylethyl) 2-Methyl Ester, (2S,4R)-
CAS No.	2306255-30-9
Molecular Formula	C13H21NO6
Molecular Weight	287.31 g/mol
Synonyms	(2S,4R)-1-(tert-Butyl) 2-methyl 1,2,4-pyrrolidinetricarboxylate; tert-Butyl (2S,4R)-2-methyl 1,2,4-pyrrolidinetricarboxylate; 1-(tert-Butoxycarbonyl)-4-(methoxycarbonyl)-L-proline methyl ester; (2S,4R)-1-Boc-4-(COOMe)-proline-OMe; (2S,4R)-1-N-Boc-4-carbomethoxyproline methyl ester; Chiral Pyrrolidine Tricarboxylate Ester; BOC-Pro(4-COOMe)-OMe (2S,4R)
EINECS	Contact for details

Quality Control

Our 1,2,4-Pyrrolidinetricarboxylic Acid, 1-(1,1-Dimethylethyl) 2-Methyl Ester, (2S,4R)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is sensitive to strong acids and organic solvents; keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to preserve optimal quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.