Description

(R)-8-Azaspiro[4.5]Decan-1-Amine Dihydrochloride is a high-purity chiral amine building block of significant interest in advanced pharmaceutical research and development. Its value lies in its rigid spirocyclic structure, which is crucial for modulating the biological activity, selectivity, and metabolic stability of novel drug candidates. This compound is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to explore novel chemical space and improve drug-like properties.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scalable synthesis of clinical trial materials and commercial APIs.
• Ligand Synthesis: Potential precursor for the development of chiral ligands and catalysts used in asymmetric synthesis.
• Bioconjugation: The amine functionality allows for conjugation to various probes, tags, or other molecular entities in chemical biology research.

Basic Information

Product Name	(R)-8-Azaspiro[4.5]Decan-1-Amine Dihydrochloride
CAS No.	2306253-66-5
Molecular Formula	C9H20Cl2N2
Molecular Weight	227.18 g/mol
Synonyms	(1R)-8-Azaspiro[4.5]decan-1-amine dihydrochloride; (R)-1-Amino-8-azaspiro[4.5]decane dihydrochloride; 8-Azaspiro[4.5]decan-1-amine, (1R)-, dihydrochloride; UNII-9H8P3W5K6F; 9H8P3W5K6F; (R)-1,8-Diazaspiro[4.5]decane dihydrochloride (common misnomer); (R)-Spiro[4.5]decan-1-amine, 8-aza-, dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-8-Azaspiro[4.5]Decan-1-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are provided to guarantee identity, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.