Description

2,7-Diazaspiro[4.4]Nonane-2-Carboxylic Acid, 1,1-Dimethylethyl Ester, (5S)- is a high-value, stereochemically defined spirocyclic building block crucial for modern pharmaceutical research and development. This compound serves as a key chiral intermediate in the synthesis of complex molecules, particularly for targeting challenging biological pathways. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the construction of spirocyclic scaffolds in new drug discovery programs.
• Protease Inhibitor Development: Used in the research and synthesis of potential inhibitors for various protease enzymes.
• Central Nervous System (CNS) Drug Discovery: Employed in creating novel compounds targeting neurological disorders due to its ability to influence pharmacokinetic properties like blood-brain barrier penetration.
• Peptidomimetics & Constrained Peptides: Acts as a rigid, three-dimensional building block to replace peptide bonds, enhancing metabolic stability and receptor selectivity.
• Chemical Biology & Probe Development: Utilized in the design of molecular probes to study enzyme function and protein-protein interactions.
• Process Chemistry & Scale-Up: Serves as a starting material for the development of robust, scalable synthetic routes to advanced intermediates under GMP conditions.

Basic Information

Product Name	2,7-Diazaspiro[4.4]Nonane-2-Carboxylic Acid, 1,1-Dimethylethyl Ester, (5S)-
CAS No.	2306252-57-1
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	(5S)-1,1-Dimethylethyl 2,7-Diazaspiro[4.4]nonane-2-carboxylate; tert-Butyl (5S)-2,7-diazaspiro[4.4]nonane-2-carboxylate; (5S)-Boc-2,7-diazaspiro[4.4]nonane; (S)-tert-Butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate; (5S)-N-Boc-2,7-diazaspiro[4.4]nonane; Boc-(5S)-2,7-diazaspiro[4.4]nonane; (S)-2-(tert-Butoxycarbonyl)-2,7-diazaspiro[4.4]nonane
EINECS	Contact for details

Quality Control

Our 2,7-Diazaspiro[4.4]Nonane-2-Carboxylic Acid, 1,1-Dimethylethyl Ester, (5S)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Enantiomeric Excess)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.