Description

1-(p-Methoxyphenylsulfonyl)-7-Azaindole-3-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and building block designed for complex organic synthesis. This compound matters for its crucial role as a key precursor in modern cross-coupling reactions, enabling the efficient construction of novel heterocyclic scaffolds. It is primarily needed by research scientists and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients, particularly in medicinal chemistry programs targeting kinase inhibitors and other biologically relevant molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, especially for targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester reagent for forming carbon-carbon bonds to construct complex molecular architectures.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies for new chemical entities.
• Kinase Inhibitor Development: Key precursor in the synthesis of compounds targeting various kinase enzymes due to the privileged 7-azaindole scaffold.
• Agrochemical Research: Employed in the discovery and synthesis of new active ingredients for crop protection.
• Chemical Biology Probes: Utilized to create labeled or tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	1-(p-Methoxyphenylsulfonyl)-7-Azaindole-3-Boronic Acid Pinacol Ester
CAS No.	2304635-47-8
Molecular Formula	C20H21BN2O5S
Molecular Weight	412.27 g/mol
Synonyms	1-[(4-Methoxyphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine-3-boronic acid pinacol ester; 7-Azaindole-3-boronic acid pinacol ester, 1-(p-methoxyphenylsulfonyl)-; 1H-Pyrrolo[2,3-b]pyridine-3-boronic acid, 1-[(4-methoxyphenyl)sulfonyl]-, 1,1-dimethylethyl ester; 1-(4-Methoxybenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-boronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(4-methoxybenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine; CAS 2304635-47-8
EINECS	Contact for details

Quality Control

Our 1-(p-Methoxyphenylsulfonyl)-7-Azaindole-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature is between 2°C and 8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.