Description

Hoocch2O-Peg4-Ch2Ch2Cootbu is a specialized polyethylene glycol (PEG)-based linker molecule featuring a carboxylic acid and a tert-butyl ester as terminal functional groups. This bifunctional structure is critical for creating cleavable, hydrophilic spacers in bioconjugation and advanced drug delivery systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotech, and advanced materials sectors for developing targeted therapeutics and functionalized biomaterials.

Application

• Bioconjugation Linker: Serves as a versatile spacer for attaching targeting ligands (e.g., antibodies, peptides) to drug payloads, nanoparticles, or diagnostic agents.
• Prodrug Synthesis: Used to create acid-labile or enzymatically cleavable prodrug constructs, enabling controlled drug release at specific disease sites.
• Polymer Modification: Functionalizes polymers and surfaces with carboxylic acid groups for subsequent coupling reactions in biomaterial engineering.
• ADC (Antibody-Drug Conjugate) Development: A key intermediate for constructing stable, hydrophilic linkers between monoclonal antibodies and potent cytotoxins.
• Peptide & Protein Modification: Facilitates site-specific PEGylation to improve the pharmacokinetic properties and stability of therapeutic peptides and proteins.
• Cross-linking Agent: Employed in the synthesis of hydrogels and polymeric networks for controlled release applications.
• Research Chemical: Used in academic and industrial R&D for exploring novel drug delivery platforms and chemical biology tools.

Basic Information

Product Name	Hoocch2O-Peg4-Ch2Ch2Cootbu
CAS No.	2304558-22-1
Molecular Formula	C21H40O11
Molecular Weight	468.54 g/mol
Synonyms	15-Aza-3,6,9,12-tetraoxapentadecan-1-oic acid, 15-[(1,1-dimethylethoxy)carbonyl]-; 4,7,10,13-Tetraoxa-16-azanonadecanedioic acid 1-tert-butyl ester; PEG4-acid-t-butyl ester; Fmoc-PEG4-CH2CH2-COOH; HOOC-PEG4-COOtBu; Carboxy-PEG4-t-butyl ester; Acid-PEG4-t-butyl ester; 3,6,9,12-Tetraoxapentadecanedioic acid, 15-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our Hoocch2O-Peg4-Ch2Ch2Cootbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.